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All three can technically build a website with a store attached, but only one of them is actually built e-commerce-first — the other two are general site builders with store features added on.
Shopify: built for selling, first and foremost
A Shopify Subscription is purpose-built for e-commerce — inventory management, payment processing, shipping integrations, and an enormous app ecosystem for extending functionality. If selling products at any real scale is the primary goal of the site, Shopify's e-commerce infrastructure is more mature than what Wix or Squarespace offer as an add-on to a general website builder.
Wix: the most design flexibility for non-commerce sites
Wix Premium Plan gives you the most granular drag-and-drop design control of the three, which is a genuine advantage if the site is mostly informational or portfolio-based with only light e-commerce needs, rather than a full online store.
Squarespace: the best-looking templates with the least effort
A Squarespace Subscription is known for producing polished, professional-looking sites quickly with minimal design skill required — its templates are more opinionated than Wix's (less granular control) but consistently produce a cleaner result for users who don't want to fine-tune every element themselves.
Don't forget the domain and SSL layer
Regardless of builder, you'll need a domain — see .com/.net/.org Domain Registration — and most builders include basic SSL, though a dedicated SSL Certificate is worth checking if you need extended validation for e-commerce trust signals.
Migration between builders is costly, so choose deliberately
Moving an established store from one of these platforms to another means rebuilding product listings, redirecting old URLs to avoid losing SEO value, and often losing some customization entirely — it's a meaningfully bigger project than switching a simple content site, so it's worth trialing your actual product catalog on a platform before committing long-term.
Transaction fees on top of the subscription price differ by platform and by which payment processor you use — Shopify in particular charges an additional transaction fee unless you use its own payment processor, which is worth factoring into total cost rather than comparing only the base subscription price.
App marketplace depth is a real differentiator for extending functionality beyond the built-in feature set — Shopify's app ecosystem is significantly larger than Wix or Squarespace's, which matters most once your store needs specialized functionality neither platform includes natively.
SEO customization depth (control over URL structure, meta tags, structured data) differs across all three — Shopify and Squarespace both offer solid built-in SEO controls, though very fine-grained technical SEO customization is generally easier to achieve on Shopify through its broader app ecosystem.
All three offer free trial periods before requiring payment, worth building a basic version of your actual store on each before making a final decision.
All three provide built-in analytics dashboards for tracking visitor traffic and sales, worth reviewing regularly regardless of which platform you choose.
The bottom line
Selling products at real scale: Shopify. Want maximum design control for a mostly non-commerce site: Wix. Want a polished result with minimal effort: Squarespace. All three are compared in Domains & Hosting's website builder section.